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UF Center of Excellence in Regenerative Health Biotechnology

Our VISION is to Position FLORIDA as the EPICENTER of Regenerative Health Biotechnology Research and Company Development within FIVE YEARS


Regenerative Health Biotechnology

  • Prevention
  • Rehabilitation
  • Cures for
    • Chronic Genetic Degenerative Diseases
    • Microbial Infections
    • Cancer
    • Traumatic Injuries

. . . Using Breakthrough Technologies

  • Gene Therapy
  • Tissue Replacement
  • Transplantation
  • Biomaterials
  • Vaccines

HOW will we realize this VISION?

  • ETC One-Time Investment
    • $10,000,000 Infrastructure Investment in a Scale-up GMP Bioprocessing Facility
  • UF One-Time Investment
    • $3,600,000 Facilities Purchase
  • UF Ongoing Investment
    • Add Research Faculty
    • Expand Academic Programs
    • Enhance Commercialization & Workforce Development


GMP Bioprocessing Facility, Location: Progress Corporate Park, Sid Martin Biotechnology Development Incubator, Bioprocessing Facility

GMP Bioprocessing Facility will provide:

45,000 Square Feet
  • Microbial Fermentation
    • To develop therapeutic products
  • Vector Production
    • To advance gene therapy
  • Cell Culture Facilities
    • To advance adult stem sell research
  • Workforce Development 45,000 Square Feet
    • In Biotech, Regulatory Affairs & Bioinformatics

ETC Funds

ETC Funds
Renovation & Equipment: 18 Months

$4,049,486: Microbial Fermentation
$3,486,664: Vector Production Facility
$1,560,600: Stage 2 Vector & Production
$500,000: Adult Stem Cell Culture Facility
$403,250: Verification & QA Setup
$10,000,000 – TOTAL


What’s in Place to Accomplish This VISION?

2001-2002

  1. Research Engine:
    • $437,000,000 in UF Funded
      • $225,000,000 Health Sciences
    • 4,000 Graduate Faculty
    • 9,067 Graduate Students
  2. Critical Mass of Regenerative Health Companies
    Alachua county

Sid Martin Biotechnology Development Incubator (BDI), Opened 1995, 35,000 sq. ft., 19 Labs, 13 Offices, Small and large animal facilities
  1. Superior UF Technology Transfer
    2001-2002
    • 77 Patents
    • 59 Licenses/Options
    • $31,617,349 Income
    • 2 Start-ups (from UF Technologies)
  2. Robust Regional VC Community
    • Inflexion Partners (Gainesville)
    • Springboard Capital (Jacksonville)
    • Advantage Capital Partners (Tampa)
    • Eno River Capital (Eno River)
    • Palm Beach Capital Advisors
  3. Expanding and Highly Trained Workforce
    • University of Florida: Ph.D., M.S., B.S. in Biosciences
    • Santa Fe Community College (Gainesville): A.S. Degree in Biotechnology
    • Florida Community College of Jacksonville: Bioinformatics Initiative

    photo

  4. World-Class Faculty in Regenerative Health Research
    • McKnight Brain Institute
    • Powell Gene Therapy Center
    • Center for Mammalian Genetics/Epigenetics
    • Adult Stem Cell Consortium
    • Shands Cancer Center
    • The Biotechnology Program – ICBR Core Research Support Labs


2001-2002 UF Funded Research, Powell Gene Therapy Center: $21,000,000, Center for Mammalian Genetics/ Epigenetics: $12,000,000, Adult Stem Cell Consortium: $3,000,000, Microbial Research: $600,000, Total $36,600,000

Research Focus

Research Challenges
Control of Gene Expression:

  • Gene Therapy
  • Adult Stem Cell Transplantation
  • Production of Biologicals

Epigenetics: Epigenetics Regulation: the same set of genes but with expressions (structures) of those genes during different life stages

What UF Adds to CERHB:

  • 3 New Senior Faculty in Epigenetics
  • 2 New Senior Faculty in Bioprocess Engineering & Systems Integration
  • 2 New Support Scientists – Bioinformatics
  • 2 New Support Scientists – Proteomics

$6,701,000 Investment over 5 years
$3,600,000 Purchase of Existing Building

The NEED for Bioprocessing

Pharmaceutical Industry: $300 Billion in 2010

50% Biotech Products



Major Bioprocessing Obstacles

  • International shortage of facilities
  • Growth is in dedicated facilities
  • Scarce outsource capacity for early stage companies
  • Unmet academic research needs
  • Demand will exceed capacity by factor of 4 by 2005

The CERHB Facility Impact

Catalyst for ...
  • RESEARCH scale-up statewide
  • PRODUCT scale-up
  • International RESOURCE
  • Company RELOCATION to Florida
  • Company START-UPS
  • Faculty/Student RECRUITMENT

Sustainability and Leadership


Revenue to Sustain CERHB

Collaborations

NASA Collaboration

NASA: Kennedy Space Center & Johnson Space Center

  • $4,750,000 — Space Biotechnology and Commercial Applications grant (funds from KSC)
    • Space Agriculture and Biotechnology Research and Education (SABRE) Center ($2M)
    • Integrated Smart Nanosensors for Biotechnology Applications ($1.5M)
    • Commercial Applications and University Partnerships ($1.25M)
  • Bioprocessing Systems Engineering Expertise

Private Sector Collaborators

  • Enterprise North Florida Corporation
  • BioFlorida, Inc.
  • Gainesville Chamber of Commerce
  • Venture Capital Firms
    • Inflexion
    • Eno River Capital
    • Advantage Capital
    • Palm Beach Capital
    • Springboard Capital

Workforce Development

Graduate Education

  • Health Science Center Interdisciplinary Programs:
    • The Business of Biotechnology
    • Regulatory Affairs
    • Intellectual Property
    • MS/MSM Program in Biotechnology & Business
    • Capstone Program In Biotechnology

Santa Fe Community College Programs

  • Biotechnology Technician – A.S. Degree
  • Bioprocessing Technologies
  • Regulatory Affairs
  • Training Site at the CERHB Facility

Florida Community College at Jacksonville

Bioinformatics Program

  • Curriculum Development
  • Faculty Training
  • Collaborative Teaching

"Best Value" for Florida

One-time $10,000,000 ETC Investment in Research Infrastructure:

  • Self-sufficient GMP Bioprocessing Facility
  • Employ 150
  • Generate revenue
  • Commercial development of university technologies
  • Produce two new companies/year

"Best Value" for Florida

  • Develop & grow regional Biotechnology companies
  • Attract world-class faculty and students
  • Innovative university academic paths
  • Research infrastructure for strong collaborations with NASA and others
  • Community College curriculum expansion
  • Workforce development at various levels

VISION

FLORIDA will become the Epicenter for Regenerative Health Biotechnology with robust academic, research, and commercial programs within five years.