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Our VISION is to Position FLORIDA as the EPICENTER of Regenerative Health Biotechnology Research and Company Development within FIVE YEARS

Regenerative Health Biotechnology

• Prevention
• Rehabilitation
• Cures for
  • Chronic Genetic Degenerative Diseases
  • Microbial Infections
  • Cancer
  • Traumatic Injuries

. . . Using Breakthrough Technologies

• Gene Therapy
• Tissue Replacement
• Transplantation
• Biomaterials
• Vaccines

HOW will we realize this VISION?

• ETC One-Time Investment
  • $10,000,000 Infrastructure Investment in a Scale-up GMP Bioprocessing Facility
• UF One-Time Investment
  • $3,600,000 Facilities Purchase
• UF Ongoing Investment
  • Add Research Faculty
  • Expand Academic Programs
  • Enhance Commercialization & Workforce Development

GMP Bioprocessing Facility will provide:

• Microbial Fermentation
  • To develop therapeutic products
• Vector Production
  • To advance gene therapy
• Cell Culture Facilities
  • To advance adult stem sell research
• Workforce Development 45,000 Square Feet
  • In Biotech, Regulatory Affairs & Bioinformatics

ETC Funds
Renovation & Equipment: 18 Months

$4,049,486: Microbial Fermentation
$3,486,664: Vector Production Facility
$1,560,600: Stage 2 Vector & Production
$500,000: Adult Stem Cell Culture Facility
$403,250: Verification & QA Setup
$10,000,000 – TOTAL

What’s in Place to Accomplish This VISION?

2001-2002

1. Research Engine:
   • $437,000,000 in UF Funded
     • $225,000,000 Health Sciences
   • 4,000 Graduate Faculty
   • 9,067 Graduate Students
2. Critical Mass of Regenerative Health Companies
   

4. Superior UF Technology Transfer
   2001-2002
   • 77 Patents
   • 59 Licenses/Options
   • $31,617,349 Income
   • 2 Start-ups (from UF Technologies)
5. Robust Regional VC Community
   • Inflexion Partners (Gainesville)
   • Springboard Capital (Jacksonville)
   • Advantage Capital Partners (Tampa)
   • Eno River Capital (Eno River)
   • Palm Beach Capital Advisors
6. Expanding and Highly Trained Workforce
   • University of Florida: Ph.D., M.S., B.S. in Biosciences
   • Santa Fe Community College (Gainesville): A.S. Degree in Biotechnology
   • Florida Community College of Jacksonville: Bioinformatics Initiative

   

7. World-Class Faculty in Regenerative Health Research
   • McKnight Brain Institute
   • Powell Gene Therapy Center
   • Center for Mammalian Genetics/Epigenetics
   • Adult Stem Cell Consortium
   • Shands Cancer Center
   • The Biotechnology Program – ICBR Core Research Support Labs

Research Focus

Research Challenges
Control of Gene Expression:

• Gene Therapy
• Adult Stem Cell Transplantation
• Production of Biologicals

What UF Adds to CERHB:

• 3 New Senior Faculty in Epigenetics
• 2 New Senior Faculty in Bioprocess Engineering & Systems Integration
• 2 New Support Scientists – Bioinformatics
• 2 New Support Scientists – Proteomics

The NEED for Bioprocessing

50% Biotech Products

Major Bioprocessing Obstacles

• International shortage of facilities
• Growth is in dedicated facilities
• Scarce outsource capacity for early stage companies
• Unmet academic research needs
• Demand will exceed capacity by factor of 4 by 2005

The CERHB Facility Impact

• RESEARCH scale-up statewide
• PRODUCT scale-up
• International RESOURCE
• Company RELOCATION to Florida
• Company START-UPS
• Faculty/Student RECRUITMENT

Sustainability and Leadership

Collaborations

NASA Collaboration

NASA: Kennedy Space Center & Johnson Space Center

• $4,750,000 — Space Biotechnology and Commercial Applications grant (funds from KSC)
  • Space Agriculture and Biotechnology Research and Education (SABRE) Center ($2M)
  • Integrated Smart Nanosensors for Biotechnology Applications ($1.5M)
  • Commercial Applications and University Partnerships ($1.25M)
• Bioprocessing Systems Engineering Expertise

Private Sector Collaborators

• Enterprise North Florida Corporation
• BioFlorida, Inc.
• Gainesville Chamber of Commerce
• Venture Capital Firms
  • Inflexion
  • Eno River Capital
  • Advantage Capital
  • Palm Beach Capital
  • Springboard Capital

Workforce Development

Graduate Education

• Health Science Center Interdisciplinary Programs:
  • The Business of Biotechnology
  • Regulatory Affairs
  • Intellectual Property
  • MS/MSM Program in Biotechnology & Business
  • Capstone Program In Biotechnology

Santa Fe Community College Programs

• Biotechnology Technician – A.S. Degree
• Bioprocessing Technologies
• Regulatory Affairs
• Training Site at the CERHB Facility

Florida Community College at Jacksonville

Bioinformatics Program

• Curriculum Development
• Faculty Training
• Collaborative Teaching

"Best Value" for Florida

One-time $10,000,000 ETC Investment in Research Infrastructure:

• Self-sufficient GMP Bioprocessing Facility
• Employ 150
• Generate revenue
• Commercial development of university technologies
• Produce two new companies/year

"Best Value" for Florida

• Develop & grow regional Biotechnology companies
• Attract world-class faculty and students
• Innovative university academic paths
• Research infrastructure for strong collaborations with NASA and others
• Community College curriculum expansion
• Workforce development at various levels

VISION

FLORIDA will become the Epicenter for Regenerative Health Biotechnology with robust academic, research, and commercial programs within five years.

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